{"id":1525,"date":"2023-11-30T14:34:25","date_gmt":"2023-11-30T05:34:25","guid":{"rendered":"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/smd\/?page_id=1525"},"modified":"2023-12-14T14:31:49","modified_gmt":"2023-12-14T05:31:49","slug":"progress","status":"publish","type":"page","link":"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/smd\/index.php\/kenkyu\/progress\/","title":{"rendered":"\u690d\u7269\u30db\u30eb\u30e2\u30f3\u300c\u30aa\u30fc\u30ad\u30b7\u30f3\u300d\u306e\u751f\u5408\u6210\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\uff12\u6bb5\u968e\u9175\u7d20\u53cd\u5fdc\u306b\u304a\u3051\u308b\u8abf\u7bc0\u6a5f\u69cb\u3092\u89e3\u660e"},"content":{"rendered":"<section class=\"content-single\">\n<div class=\"content-white\"><\/p>\n<div class=\"side\">\n<div class=\"a-set01\">\n\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u6728\u539f\u751f\u7269\u5b66\u7814\u7a76\u6240\u306e\u5d8b\u7530\u5e78\u4e45\u6559\u6388\u3001\u4f50\u85e4\u660e\u5b50\u8077\u54e1\u304a\u3088\u3073\u8fb2\u696d\u30fb\u98df\u54c1\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6a5f\u69cb\uff08\u8fb2\u7814\u6a5f\u69cb\uff09\u897f\u65e5\u672c\u8fb2\u696d\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u306e\u6dfb\u91ce\u548c\u96c4\u4e0a\u7d1a\u7814\u7a76\u54e1\u3089\u306e\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u690d\u7269\u30db\u30eb\u30e2\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30aa\u30fc\u30ad\u30b7\u30f3\u751f\u5408\u6210\u306e\u4e3b\u7d4c\u8def\u3067\u50cd\u304f\uff12\u6bb5\u968e\u306e\u9175\u7d20\u53cd\u5fdc\u306b\u304a\u3051\u308b\u8abf\u7bc0\u6a5f\u69cb\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002 <br \/>\n\u30aa\u30fc\u30ad\u30b7\u30f3\u306f\u690d\u7269\u306e\u6210\u9577\u3092\u3042\u3089\u3086\u308b\u5834\u9762\u3067\u5236\u5fa1\u3059\u308b\u91cd\u8981\u306a\u6210\u9577\u5236\u5fa1\u7269\u8cea\u3067\u3059\u304c\u3001\u305d\u306e\u751f\u5408\u6210\u306e\u5236\u5fa1\u6a5f\u69cb\u306b\u3064\u3044\u3066\u306f\u307b\u3068\u3093\u3069\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u521d\u767a\u306e\u751f\u5408\u6210\u9175\u7d20\u3067\u3042\u308bTAA1\/TARs<sup>\uff0a1<\/sup>\u306e\u6d3b\u6027\u304c\u305d\u306e\u751f\u6210\u7269\u3067\u3042\u308b\u30a4\u30f3\u30c9\u30fc\u30eb\u30d4\u30eb\u30d3\u30f3\u9178\uff08IPyA\uff09\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u5236\u5fa1\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u9375\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002 <br \/>\n\u672c\u6210\u679c\u306f\u30aa\u30fc\u30ad\u30b7\u30f3\u751f\u5408\u6210\u306e\u5236\u5fa1\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u690d\u7269\u304c\u3069\u306e\u3088\u3046\u306b\u6210\u9577\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u304b\u306e\u7406\u89e3\u3084\u3001\u3072\u3044\u3066\u306f\u8fb2\u4f5c\u7269\u306e\u751f\u7523\u5411\u4e0a\u306a\u3069\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002 <br \/>\n\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u7c73\u56fd\u79d1\u5b66\u30a2\u30ab\u30c7\u30df\u30fc\u7d00\u8981\uff08PNAS\u8a8c\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\uff08\u65e5\u672c\u6642\u95932022\u5e746\u670814\u65e54\u6642\uff09\n\t\t<\/div>\n<\/p><\/div>\n<div class=\"a-set01\">\n<div class=\"table-normal\">\n<table border=\"0\" cellpadding=\"1\" cellspacing=\"1\">\n<tr>\n<td><span style=\"font-size: 13pt;\">\u7814\u7a76\u6210\u679c\u306e\u30dd\u30a4\u30f3\u30c8<br \/><\/span><\/p>\n<ul>\n<li><span style=\"font-size: 12pt;\">\u30aa\u30fc\u30ad\u30b7\u30f3\u306e\u751f\u5408\u6210\u306e\u4e3b\u7d4c\u8def\u306b\u304a\u3044\u3066\uff12\u6bb5\u968e\u306e\u9175\u7d20\u53cd\u5fdc\uff08TAA\/TARs\u3068YUCCAs<span style=\"font-size: 8pt;\">\uff0a2<\/span>\uff09\u306b\u304a\u3051\u308b\u8abf\u7bc0\u6a5f\u69cb\u3092\u89e3\u660e\u3057\u305f<br \/><\/span><\/li>\n<li><span style=\"font-size: 12pt;\">TAA\/TARs\u9175\u7d20\u306f\u751f\u6210\u7269\u3067\u3042\u308bIPyA\u306b\u3088\u308b\u8ca0\u306e\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u5236\u5fa1\u3092\u53d7\u3051\u308b\t<\/span><\/li>\n<li><span style=\"font-size: 12pt;\">\u9175\u7d20\u53cd\u5fdc\u306b\u304a\u3051\u308b\u8abf\u7bc0\u6a5f\u69cb\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306fTAA\/TARs\u304c\u9006\u53cd\u5fdc\u6d3b\u6027\u3092\u6301\u3064\u3068\u5171\u306b\u3001IPyA\u304cTAA\/TARs\u306e\u7af6\u5408\u963b\u5bb3\u5264\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u3044\u308b<br \/><\/span><\/li>\n<li><span style=\"font-size: 12pt;\">TAA\/TARs\u306e\u8abf\u7bc0\u6a5f\u69cb\u306f\u5e45\u5e83\u3044\u9ad8\u7b49\u690d\u7269\u3067\u6a5f\u80fd\u3057\u3066\u304a\u308a\u3001\u30aa\u30fc\u30ad\u30b7\u30f3\u751f\u5408\u6210\u306b\u6b20\u304b\u305b\u306a\u3044\u8abf\u7bc0\u6a5f\u69cb\u3067\u3042\u308b<br \/><\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/table><\/div>\n<\/p><\/div>\n<p><\/p>\n<section class=\"leftpart\">\n<div class=\"side\">\n<h2>\u7814\u7a76\u80cc\u666f<\/h2>\n<div class=\"a-set01\">\n\u30aa\u30fc\u30ad\u30b7\u30f3\u306f\u690d\u7269\u304c\u767a\u82bd\u3057\u3066\u67af\u308c\u308b\u307e\u3067\u690d\u7269\u306e\u6210\u9577\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u91cd\u8981\u306a\u690d\u7269\u30db\u30eb\u30e2\u30f3\u3067\u3059\u3002\u690d\u7269\u306e\u7d30\u80de\u304c\u5206\u88c2\u3057\u305f\u308a\u4f38\u9577\u3057\u305f\u308a\u3001\u679d\u5206\u304b\u308c\u3059\u308b\u5668\u5b98\u3092\u4f5c\u3063\u305f\u308a\u3059\u308b\u969b\u306b\u306f\u30aa\u30fc\u30ad\u30b7\u30f3\u304c\u91cd\u8981\u306a\u5236\u5fa1\u56e0\u5b50\u3068\u306a\u3063\u3066\u304a\u308a\u690d\u7269\u306e\u5f62\u614b\u5f62\u6210\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u6587\u732e\uff11\uff09\u3002\u4e00\u65b9\u3001\u30aa\u30fc\u30ad\u30b7\u30f3\u306b\u306f\u81f3\u9069\u6fc3\u5ea6\u304c\u3042\u308a\u3001\u81f3\u9069\u6fc3\u5ea6\u3088\u308a\u3082\u9ad8\u304f\u3066\u3082\u4f4e\u304f\u3066\u3082\u6210\u9577\u304c\u963b\u5bb3\u3055\u308c\u308b\u3068\u3044\u3046\u7279\u5fb4\u3082\u3042\u308a\u307e\u3059\u3002<br \/>\n\u5929\u7136\u578b\u306e\u30aa\u30fc\u30ad\u30b7\u30f3\u306e\u4ee3\u8868\u306f\u30a4\u30f3\u30c9\u30fc\u30eb\u9162\u9178\uff08IAA\uff09\u3067\u3059\u3002IAA\u306f\u30a2\u30df\u30ce\u9178\u306e\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\uff08Trp\uff09\u304b\u3089\uff12\u6bb5\u968e\u306e\u9175\u7d20\u53cd\u5fdc\u306b\u3088\u308aIPyA\u3092\u7d4c\u3066\u751f\u5408\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\uff11\u6bb5\u968e\u76ee\u306e\u9175\u7d20\u304cTrp\u3092IPyA\u306b\u5909\u63db\u3059\u308bTAA1\/TARs\uff08Trp\u30a2\u30df\u30ce\u57fa\u8ee2\u79fb\u9175\u7d20\uff09\u3067\u3001\uff12\u6bb5\u968e\u76ee\u306fIPyA\u3092IAA\u306b\u5909\u63db\u3059\u308bYUCCAs\uff08\u30d5\u30e9\u30d3\u30f3\u542b\u6709\u30e2\u30ce\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\uff09\u3067\u3059\uff08\u56f31\uff09\u3002\n\t\t\t<\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"leftpart\">\n<div class=\"capimage center\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/japanese\/20220610shimada-1-2.jpg\" width=\"500\" alt=\"\"><br \/>\n\t\t\t\t<span class=\"caption\" style=\"width:90%;\" >\u56f31\u3000\u30aa\u30fc\u30ad\u30b7\u30f3\u751f\u5408\u6210\u7d4c\u8def\u56f3\uff1aTrp\u304b\u3089IPyA\u3092\u7d4c\u7531\u3057\u3066IAA\u304c2\u6bb5\u968e\u9175\u7d20\u53cd\u5fdc\uff08TAA1\/TARs\u3068YUCCAs\uff09\u306b\u3088\u308a\u751f\u5408\u6210\u3055\u308c\u308bTAA1\/TARs\u306fIPyA\u3092Trp\u306b\u5909\u63db\u3059\u308b\u9006\u53cd\u5fdc\u6d3b\u6027\u3092\u6301\u3061\u3001IPyA\u304a\u3088\u3073KOK2099\u306fTrp\u306e\u7af6\u5408\u963b\u5bb3\u5264\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u8d64\u3067\u793a\u3059\u77e2\u5370\u304a\u3088\u3073\u963b\u5bb3\u90e8\u5206\u3092\u89e3\u660e\u3057\u305f\u3002<\/span>\n\t\t<\/div>\n<div class=\"side\">\n<div class=\"a-set01\">\nTAA\uff11\u306e\u9175\u7d20\u53cd\u5fdc\u751f\u6210\u7269\u3067\u3042\u308a\u3001IAA\u751f\u5408\u6210\u306e\u4e2d\u9593\u4f53\u3067\u3042\u308bIPyA\u306f\u690d\u7269\u4f53\u4e2d\u306b\u306f\u3054\u304f\u5fae\u91cf\u306b\u3057\u304b\u5b58\u5728\u3057\u307e\u305b\u3093\u3002IPyA\u306f\u975e\u5e38\u306b\u4e0d\u5b89\u5b9a\u306a\u7269\u8cea\u3067\u3042\u308aIPyA\u304c\u904e\u5270\u306b\u84c4\u7a4d\u3059\u308b\u3068\u58ca\u308c\u3066\u690d\u7269\u4f53\u4e2d\u306eIAA\u306e\u91cf\u304c\u5897\u3048\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u305d\u308c\u3092\u9632\u3050\u305f\u3081\u306bIPyA\u91cf\u306e\u84c4\u7a4d\u3092\u6291\u3048\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4e00\u65b9\u3067\u679c\u5b9f\u3084\u7a2e\u5b50\u306a\u3069\u6d3b\u767a\u306b\u6210\u9577\u3059\u308b\u5668\u5b98\u3067\u306f\u6210\u9577\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u306b\u30aa\u30fc\u30ad\u30b7\u30f3\u3092\u5927\u91cf\u306b\u5408\u6210\u3057\u307e\u3059\u304c\u3001\u305d\u306e\u969b\u306b\u306fIPyA\u304c\u4e0d\u8db3\u3057\u306a\u3044\u3088\u3046\u306b\u4f9b\u7d66\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306f\u3001\u690d\u7269\u4f53\u4e2d\u306eIPyA\u306e\u84c4\u7a4d\u91cf\u3092\u5fae\u91cf\u306b\u6291\u3048\u3064\u3064\u3001\u4e0d\u8db3\u3059\u308b\u3053\u3068\u3092\u3069\u306e\u3088\u3046\u306b\u9632\u3044\u3067\u3044\u308b\u306e\u304b\u4e0d\u660e\u3067\u3057\u305f\u3002\u307e\u305f\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u690d\u7269\u3092\u4f7f\u3063\u3066\uff12\u6bb5\u76ee\u306e\u9175\u7d20\u3067\u3042\u308bYUCCA\u3092\u904e\u5270\u767a\u73fe\u3055\u305b\u308b\u3068\u30aa\u30fc\u30ad\u30b7\u30f3\u904e\u5270\u306b\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u521d\u767a\u9175\u7d20\u306eTAA1\u3092\u904e\u5270\u767a\u73fe\u3057\u3066\u3082\u30aa\u30fc\u30ad\u30b7\u30f3\u904e\u5270\u306b\u306f\u306a\u3089\u305a\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3082\u8b0e\u3067\u3057\u305f\u3002 \u3000<br \/>\n\u672c\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u3001\u30aa\u30fc\u30ad\u30b7\u30f3\u751f\u5408\u6210\u3092\u963b\u5bb3\u3059\u308b\u5316\u5408\u7269\u3092\u767a\u898b\u3057\u3001\u7814\u7a76\u3092\u9032\u3081\u3066\u304d\u307e\u3057\u305f\uff08\u53c2\u8003\u6587\u732e\uff12\uff0c\uff13\uff0c\uff14\uff09\u3002\u672c\u7814\u7a76\u3067\u306f\u3053\u308c\u307e\u3067\u306e\u77e5\u898b\u3092\u6d3b\u7528\u3057\u3001\u751f\u5408\u6210\u4e2d\u9593\u4f53IPyA\u306e\u985e\u4f3c\u5316\u5408\u7269\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u985e\u4f3c\u5316\u5408\u7269\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308aTAA1\u9175\u7d20\u6d3b\u6027\u306b\u5bfe\u3059\u308bIPyA\u306e\u50cd\u304d\u3068\u30aa\u30fc\u30ad\u30b7\u30f3\u751f\u5408\u6210\u306e\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e\u306b\u3064\u306a\u304c\u308a\u307e\u3057\u305f\u3002\n\t\t\t<\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"leftpart\">\n<div class=\"side\">\n<h2>\u7814\u7a76\u5185\u5bb9<\/h2>\n<div class=\"a-set01\">\n\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306b\u304a\u3044\u3066\u3001TAA1\/TARs\u304c\u305d\u306e\u751f\u6210\u7269\u3067\u3042\u308bIPyA\uff08\u307e\u305f\u306f\u985e\u4f3c\u5316\u5408\u7269\uff09\u306b\u3088\u3063\u3066\u8ca0\u306e\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u5236\u5fa1\u3092\u53d7\u3051\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\u305d\u306e\u5206\u5b50\u6a5f\u69cb\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001TAA1\u306fTrp\u304b\u3089IAA\u751f\u5408\u6210\u306e\u4e2d\u9593\u4f53\u3067\u3042\u308bIPyA\u3092\u751f\u5408\u6210\u3059\u308b\u6d3b\u6027\u306b\u52a0\u3048\u3066IPyA\u3092Trp\u306b\u623b\u3059\u9006\u9175\u7d20\u6d3b\u6027\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\u3053\u308c\u30892\u3064\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066IPyA\u306e\u91cf\u3092\u4f4e\u304f\u4fdd\u3061\u306a\u304c\u3089\u3001\u540c\u6642\u306b\u4e0d\u8db3\u3059\u308b\u3053\u3068\u3082\u9632\u3044\u3067\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001IPyA\u306e\u985e\u4f3c\u5316\u5408\u7269\u3092\u958b\u767a\u3057\u3066\u305d\u306e\u6d3b\u6027\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u985e\u4f3c\u5316\u5408\u7269\u306fTAA1\u9175\u7d20\u306e\u7af6\u5408\u963b\u5bb3\u5264\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u56f32\uff09\u3002\u3053\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3068IPyA\u985e\u4f3c\u5316\u5408\u7269\u306b\u3088\u308b\u9175\u7d20\u963b\u5bb3\u6d3b\u6027\u306f\u3001\u30a4\u30cd\u3084\u30c8\u30de\u30c8\u3067\u3082\u6a5f\u80fd\u3057\u3066\u304a\u308a\u3001\u591a\u304f\u306e\u690d\u7269\u306b\u304a\u3044\u3066\u666e\u904d\u7684\u306b\u5b58\u5728\u3059\u308bIAA\u751f\u5408\u6210\u8abf\u7bc0\u6a5f\u69cb\u3067\u3042\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u307e\u3057\u305f\u3002\n\t\t\t\t<\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"leftpart\">\n<div class=\"capimage center\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/japanese\/20220610shimada-2-2.jpg\" width=\"450\" alt=\"\"><br \/>\n\t\t\t\t\t<span class=\"caption\" style=\"width:90%;\">\u56f32\u3000IPyA\u985e\u4f3c\u5316\u5408\u7269\u306e\u69cb\u9020\u3068\u963b\u5bb3\u4f5c\u7528\uff1aIPyA\u306f\u30b1\u30c8\u5f62\u3068\u30a8\u30ce\u30fc\u30eb\u5f62\u306e\u9593\u306e\u4e92\u5909\u7570\u6027\u4f53\u3067\u3042\u308b\u3002\u30a8\u30ce\u30fc\u30eb\u5f62IPyA\u306e\u985e\u4f3c\u5316\u5408\u7269\uff08KOK2099\u3068KOK2052BP\uff09\u3092\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306b\u4e0e\u3048\u308b\u3068\u6839\u306e\u4f38\u9577\u963b\u5bb3\u306a\u3069\u306e\u6210\u9577\u963b\u5bb3\u304c\u307f\u3089\u308c\u308b\u3002\u3053\u306e\u963b\u5bb3\u306fIAA\u306e\u540c\u6642\u6295\u4e0e\u306b\u3088\u308a\u56de\u5fa9\u3059\u308b\u3053\u3068\u7b49\u304b\u3089\u985e\u4f3c\u5316\u5408\u7269\u306f\u690d\u7269\u4f53\u5185\u3067\u30aa\u30fc\u30ad\u30b7\u30f3\u751f\u5408\u6210\u3092\u5f37\u304f\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/span>\n\t\t\t<\/div>\n<div class=\"side\">\n<div class=\"a-set01\">\n\u3064\u307e\u308a\u3001IPyA\u306b\u3088\u308b\u8ca0\u306e\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u5236\u5fa1\u306f\u3001Trp\u30a2\u30df\u30ce\u57fa\u8ee2\u79fb\u9175\u7d20\u6d3b\u6027\u306e\u53ef\u9006\u6027\u3068IPyA\u306b\u3088\u308bTAA1\/TARs\u9175\u7d20\u6d3b\u6027\u306e\u7af6\u5408\u7684\u963b\u5bb3\u306e\u4e21\u65b9\u306b\u3088\u3063\u3066\u9054\u6210\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\uff08\u56f33\uff09\u3002TAA1\u9175\u7d20\u306b\u5bfe\u3059\u308bIPyA\u306eKm\u5024\u306f0.7 \u00b5M\u3001Trp\u306eKm\u5024\u306f43.6 \u00b5M\u3067\u3042\u308a\u3001\u9175\u7d20\u306e\u751f\u5316\u5b66\u7684\u306a\u7279\u5fb4\u3082IPyA\u3092\u4f4e\u3044\u30ec\u30d9\u30eb\u306b\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u512a\u308c\u305f\u7279\u6027\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308a\u30012\u3064\u306e\u751f\u5408\u6210\u9175\u7d20\u3001TAA1\/TARs\u306b\u3088\u308bIPyA\u5408\u6210\u3068YUCCAs\u306b\u3088\u308bIPyA\u6d88\u8cbb\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5909\u5316\u3057\u3066\u3082TAA1\/TARs\u306fIPyA\u306e\u904e\u5270\u84c4\u7a4d\u3084\u904e\u5c0f\u84c4\u7a4d\u3092\u9632\u3050\u91cd\u8981\u306a\u8abf\u7bc0\u6a5f\u80fd\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\n\t\t\t\t<\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"leftpart\">\n<div class=\"capimage center\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/japanese\/20220610shimada-3-2.jpg\" width=\"350\" alt=\"\"><br \/>\n\t\t\t\t\t<span class=\"caption\" style=\"width: 90%;\">\u56f33\u3000TAA1\u306e\u30a2\u30df\u30ce\u57fa\u8ee2\u79fb\u53cd\u5fdc\u6a21\u5f0f\u56f3\uff1a\u30a2\u30df\u30ce\u57fa\u8ee2\u79fb\u9175\u7d20\u306f\u30a2\u30df\u30ce\u9178\u306e\u30a2\u30df\u30ce\u57fa\u3092\u53d6\u308a\u9664\u304d2-\u30aa\u30ad\u30bd\u9178\u306b\u5909\u63db\u3059\u308b\u53cd\u5fdc\u3068\u30012-\u30aa\u30ad\u30bd\u9178\u306b\u30a2\u30df\u30ce\u57fa\u3092\u8ee2\u79fb\u3057\u3066\u30a2\u30df\u30ce\u9178\u306b\u5909\u63db\u3059\u308b\u53cd\u5fdc\u306e\uff12\u3064\u306e\u53cd\u5fdc\u3092\u884c\u3046\u3002TAA1\uff08PLP\u578b\uff09\u306fTrp\u306e\u30a2\u30df\u30ce\u57fa\u3092\u53d6\u308a\u9664\u304dIPyA\u306b\u5909\u63db\u3059\u308b\u3068\u3068\u3082\u306bTAA1\uff08PMP\u578b\uff09\u306b\u306a\u308b\u3002TAA1\uff08PMP\u578b\uff09\u306f\u30d4\u30eb\u30d3\u30f3\u9178\uff08Pyr\uff09\u306b\u30a2\u30df\u30ce\u57fa\u3092\u8ee2\u79fb\u3057\u30a2\u30e9\u30cb\u30f3\uff08Ala\uff09\u306b\u5909\u63db\u3059\u308b\u3068\u3068\u3082\u306bTAA1\uff08PLP\u578b\uff09\u306b\u623b\u308b\u3002\u3053\u306e\u53cd\u5fdc\u306f\u53ef\u9006\u7684\u3067\u3042\u308a\u3001\u9175\u7d20\u5206\u5b50\u306e\u5171\u901a\u306e\u90e8\u4f4d\u3067\u884c\u308f\u308c\u308b\u305f\u3081\u3001IPyA\u304a\u3088\u3073\u305d\u306e\u985e\u4f3c\u5316\u5408\u7269\u306fTrp\u306b\u5bfe\u3059\u308b\u7af6\u5408\u963b\u5bb3\u5264\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002<\/span>\n\t\t\t<\/div>\n<\/section>\n<section class=\"leftpart\">\n<div class=\"side\"><\/p>\n<h2>\u4eca\u5f8c\u306e\u5c55\u958b<\/h2>\n<div class=\"a-set01\">\n\u30aa\u30fc\u30ad\u30b7\u30f3\u306f\u690d\u7269\u306e\u6210\u9577\u5236\u5fa1\u3084\u3001\u679c\u5b9f\u3084\u7a2e\u5b50\u306e\u5927\u304d\u3055\u3092\u6c7a\u3081\u308b\u305f\u3081\u306b\u3082\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3059\u3002\u4eca\u5f8c\u306f\u4eca\u56de\u660e\u3089\u304b\u3068\u3057\u305f\u77e5\u898b\u3092\u3055\u3089\u306b\u767a\u5c55\u3055\u305b\u3001\u690d\u7269\u304c\u3044\u3064\u3001\u3069\u306e\u3088\u3046\u306b\u30aa\u30fc\u30ad\u30b7\u30f3\u91cf\u3092\u7684\u78ba\u306b\u8abf\u7bc0\u3057\u3066\u4f5c\u308a\u3001\u81ea\u8eab\u306e\u4f53\u4f5c\u308a\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u305d\u306e\u4ed5\u7d44\u307f\u306e\u89e3\u660e\u306b\u767a\u5c55\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u4eca\u56de\u958b\u767a\u3057\u305fIPyA\u306e\u985e\u4f3c\u5316\u5408\u7269\u3088\u308a\u3082\u52b9\u679c\u306e\u9ad8\u3044\u751f\u5408\u6210\u963b\u5bb3\u5264\u306e\u958b\u767a\u3084\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306a\u3069\u306b\u3088\u308a\u3001\u30aa\u30fc\u30ad\u30b7\u30f3\u751f\u5408\u6210\u306e\u5236\u5fa1\u304c\u53ef\u80fd\u3068\u306a\u308c\u3070\u3001\u8fb2\u4f5c\u7269\u3084\u30d0\u30a4\u30aa\u71c3\u6599\u306a\u3069\u306e\u8cc7\u6e90\u3068\u306a\u308b\u30d0\u30a4\u30aa\u30de\u30b9\u306e\u751f\u7523\u5411\u4e0a\u306a\u3069\u306b\u5411\u3051\u305f\u65b0\u305f\u306a\u6280\u8853\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\n\t\t\t\t<\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"leftpart\">\n<div class=\"side\">\n<h2>\u7814\u7a76\u8cbb<\/h2>\n<div class=\"a-set01\">\n\u672c\u7814\u7a76\u306f\u3001\u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1\u30fb\u57fa\u76e4B\u3001\u304a\u3088\u3073\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u5b66\u9577\u88c1\u91cf\u4e8b\u696d\u8cbb\u306e\u652f\u63f4\u3092\u53d7\u3051\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002\n\t\t\t\t<\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"leftpart\">\n<div class=\"side\">\n<h2>\u8ad6\u6587\u60c5\u5831<\/h2>\n<div class=\"a-set01\">\n\u30bf\u30a4\u30c8\u30eb\uff1a Indole-3-pyruvic acid regulates TAA1 activity, which plays a key role in coordinating the two steps of auxin biosynthesis <br \/>\n\u8457\u8005\uff1a Akiko Sato, Kazuo Soeno, Rie Kikuchi, Megumi Narukawa-Nara, Chiaki Yamazaki, Yusuke Kakei, Ayako Nakamura, Yukihisa Shimada  <br \/>\n\u63b2\u8f09\u96d1\u8a8c\uff1a PNAS <br \/>\nDOI\uff1a <a href=\"https:\/\/doi.org\/10.1073\/pnas.2203633119\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1073\/pnas.2203633119 <\/a>\n\t\t\t<\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"leftpart\">\n<div class=\"side\">\n<h4>\u7528\u8a9e\u8aac\u660e<\/h4>\n<div class=\"a-set01\">\n\uff0a1 TAA1\/TARs\uff1a\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306e\u5909\u7570\u4f53\u304b\u3089\u898b\u3044\u3060\u3055\u308c\u305f\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u30a2\u30df\u30ce\u57fa\u8ee2\u79fb\u9175\u7d20TAA1\uff08TRYPTOPHAN AMINOTRANSFERASE of ARABIDOPSIS 1\uff09\u3068\u305d\u306e\u540c\u65cf\u9175\u7d20\u7fa4TARs\uff08TRYPTOPHAN AMINOTRANSFERASE RELATEDs\uff09\u306e\u7dcf\u79f0\u3002  <br \/>\n\uff0a2 YUCCAs\uff1a\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306e\u5909\u7570\u4f53\u304b\u3089\u898b\u3044\u3060\u3055\u308c\u305f\u30d5\u30e9\u30d3\u30f3\u542b\u6709\u30e2\u30ce\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\uff08YUCCA\uff09\u306e\u540c\u65cf\u9175\u7d20\u7fa4\u306e\u7dcf\u79f0\u3002\n\t\t\t<\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"leftpart\">\n<div class=\"side\">\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<div class=\"a-set01\">\n1)\t\u690d\u7269\u306e\u4f53\u306e\u4e2d\u3067\u306f\u4f55\u304b\u8d77\u3053\u3063\u3066\u3044\u308b\u306e\u304b\uff08\u30d9\u30ec\u51fa\u7248\uff09\u3001\u5d8b\u7530\u5e78\u4e45\u3001\u8431\u539f\u6b63\u55e3\u8457 <br \/>\n2)\t\u6dfb\u91ce\u548c\u96c4\u3001\u5d8b\u7530\u5e78\u4e45 (2019\uff09 <br \/>\n\u3000\u30a4\u30f3\u30c9\u30fc\u30eb-3-\u30d4\u30eb\u30d3\u30f3\u9178\u3092\u7d4c\u7531\u3059\u308b\u30aa\u30fc\u30ad\u30b7\u30f3\u751f\u5408\u6210\u7d4c\u8def\u306e\u963b\u5bb3\u5264 <br \/>\n\u3000\uff0d\u751f\u5408\u6210\u6a5f\u69cb\u306e\u89e3\u660e\u3084\u690d\u7269\u8abf\u7bc0\u5264\u958b\u767a\u306b\u5411\u3051\u305f\u30b1\u30df\u30ab\u30eb\u30c4\u30fc\u30eb\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\uff0d <br \/>\n\u3000\u65e5\u672c\u8fb2\u85ac\u5b66\u4f1a\u8a8c 44: 67-68 <br \/>\n3)\t\u4f50\u85e4\u660e\u5b50\u3001\u6dfb\u91ce\u548c\u96c4\u3001\u7acb\u6728\u7f8e\u4fdd\u3001\u5d8b\u7530\u5e78\u4e45\uff082019\uff09 <br \/>\n\u3000\u30aa\u30fc\u30ad\u30b7\u30f3\u3092\u5229\u7528\u3057\u305f\u679c\u5b9f\u306e\u6210\u719f\u5236\u5fa1\u3000\uff5e\u30e2\u30e2\u3092\u984c\u6750\u3068\u3057\u3066 <br \/>\n\u3000\u30a2\u30b0\u30ea\u30d0\u30a4\u30aa 3:20-24 <br \/>\n4)\t\u6dfb\u91ce\u548c\u96c4\u3001\u7acb\u6728\u7f8e\u4fdd\u3001\u5d8b\u7530\u5e78\u4e45\uff082017\uff09 <br \/>\n\u3000\u690d\u7269\u30db\u30eb\u30e2\u30f3\u300c\u30aa\u30fc\u30ad\u30b7\u30f3\u300d\u306e\u751f\u5408\u6210\u963b\u5bb3\u5264\u306e\u958b\u767a\u3068\u690d\u7269\u6210\u9577\u8abf\u7bc0\u5264\u3068\u3057\u3066\u306e\u5fdc\u7528 <br \/>\n\u3000\u690d\u8abf 50(11):17-24\n\t\t\t<\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"leftpart linkset\">\n<div class=\"link-bt-set\">\n<div class=\"link-list-div\">\n<ul>\n<li><a href=\"https:\/\/www.yokohama-cu.ac.jp\/news\/2022\/dr3e64000001q1lo-att\/20220610shimadayukihisa.pdf\" target=\"_blank\" onclick=\"ga('send', 'event', 'Download', 'click', 'https:\/\/www.yokohama-cu.ac.jp\/news\/2022\/dr3e64000001q1lo-att\/20220610shimadayukihisa.pdf')\" rel=\"noopener\">\u8a18\u8005\u767a\u8868\u8cc7\u6599<img decoding=\"async\" src=\"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/japanese\/icon_pdf.png\"><br \/>\n\t\t\t\t\t<\/a><\/li>\n<\/ul><\/div>\n<\/p><\/div>\n<\/section>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u6728\u539f\u751f\u7269\u5b66\u7814\u7a76\u6240\u306e\u5d8b\u7530\u5e78\u4e45\u6559\u6388\u3001\u4f50\u85e4\u660e\u5b50\u8077\u54e1\u304a\u3088\u3073\u8fb2\u696d\u30fb\u98df\u54c1\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6a5f\u69cb\uff08\u8fb2\u7814\u6a5f\u69cb\uff09\u897f\u65e5\u672c\u8fb2\u696d\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u306e\u6dfb\u91ce\u548c\u96c4\u4e0a\u7d1a\u7814\u7a76\u54e1\u3089\u306e\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u690d\u7269\u30db\u30eb\u30e2\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30aa\u30fc\u30ad\u30b7\u30f3\u751f\u5408\u6210\u306e\u4e3b\u7d4c\u8def\u3067 [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":15,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":""},"class_list":["post-1525","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/smd\/index.php\/wp-json\/wp\/v2\/pages\/1525","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/smd\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/smd\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/smd\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/smd\/index.php\/wp-json\/wp\/v2\/comments?post=1525"}],"version-history":[{"count":10,"href":"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/smd\/index.php\/wp-json\/wp\/v2\/pages\/1525\/revisions"}],"predecessor-version":[{"id":1567,"href":"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/smd\/index.php\/wp-json\/wp\/v2\/pages\/1525\/revisions\/1567"}],"up":[{"embeddable":true,"href":"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/smd\/index.php\/wp-json\/wp\/v2\/pages\/15"}],"wp:attachment":[{"href":"https:\/\/pbiotech.sci.yokohama-cu.ac.jp\/smd\/index.php\/wp-json\/wp\/v2\/media?parent=1525"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}